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甲基丙烯?;髂z(GelMA)

甲基丙烯?;髂z(GelMA)

甲基丙烯酰化明膠(GelMA);Gelatin Methacryloyl;

EFL-GM-30/60/90

 

本材料套裝包括甲基丙烯?;髂z和光引發(fā)劑LAP。

應(yīng)用于細(xì)胞培養(yǎng)、生物3D打印、組織工程等。

本品僅限于科研用途,請(qǐng)勿用于人體。


  • 產(chǎn)品詳情
  • 使用說(shuō)明
  • 相關(guān)視頻
  • 常見問(wèn)題
  • 應(yīng)用案例
  • 用戶論文

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  • 地區(qū):北京+湖北

    商務(wù):陳婷

    聯(lián)系電話:15370307033

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    商務(wù):立立

    聯(lián)系電話:15358847978

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    商務(wù):嵐嵐

    聯(lián)系電話:15335268233

  • 地區(qū):江蘇+江西+湖南+重慶

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    聯(lián)系電話:15365358233

  • 地區(qū):廣東+安徽+云南+新疆維吾爾自治區(qū)+西藏自治區(qū)+青海+甘肅+寧夏+內(nèi)蒙古自治區(qū)

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    商務(wù):盼盼

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  • 地區(qū):上海+河北+河南+福建

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    聯(lián)系電話:19951032231

線上購(gòu)買途徑

產(chǎn)品介紹

產(chǎn)品簡(jiǎn)介

明膠(Gelatin)是經(jīng)膠原蛋白適度水解和熱變性得到的天然生物高分子材料,其具有和膠原相似的氨基酸序列。明膠側(cè)鏈上含有多種活性基團(tuán),如氨基、羧基、羥基等,多位點(diǎn)化學(xué)修飾的可能性使明膠受到眾多水凝膠研究者的青睞。

甲基丙烯?;髂z(Gelatin Methacryloyl, GelMA)為烯烴雙鍵改性明膠,其可通過(guò)紫外及可見光在光引發(fā)劑作用下迅速固化成膠。GelMA光固化水凝膠兼具天然和合成生物材料的特征,其具有適于細(xì)胞生長(zhǎng)和分化的三維(3D)結(jié)構(gòu)。GelMA水凝膠具有優(yōu)異的生物相容性和細(xì)胞反應(yīng)特性,例如提供合適的細(xì)胞粘附位點(diǎn)及蛋白水解降解性,其可以取代人工基底膜或其他天然膠原蛋白水凝膠。此外,GelMA水凝膠具有良好的機(jī)械性能,其構(gòu)建的3D微支架具有可調(diào)的機(jī)械和化學(xué)性質(zhì)。此外,GelMA具備良好的溫敏凝膠特性和可降解性,其機(jī)械性能可調(diào),能夠提供多種黏彈特性,已廣泛應(yīng)用于細(xì)胞3D培養(yǎng)、組織工程、生物3D打印等研究領(lǐng)域。

EFL團(tuán)隊(duì)推出的GelMA產(chǎn)品(EFL-GM系列)通過(guò)嚴(yán)格的原料篩選及品質(zhì)檢測(cè),具有批次穩(wěn)定、配套服務(wù)專業(yè)等優(yōu)勢(shì),自推出以來(lái),已服務(wù)哈佛、劍橋、麻省理工、港大、清華、北大、浙大、上交等國(guó)內(nèi)外高校的數(shù)千個(gè)課題組,深受國(guó)內(nèi)外科研工作者的好評(píng)與認(rèn)可。


型號(hào)規(guī)格

圖片1.jpg


產(chǎn)品應(yīng)用

細(xì)胞培養(yǎng)、生物3D打印、組織工程等。


儲(chǔ)存條件

干態(tài)套裝:室溫,3個(gè)月;4℃,12個(gè)月;-20℃,18個(gè)月。


核磁氫譜

圖片2.jpg

圖1. GelMA合成反應(yīng)原理及GM30/60/90核磁氫譜

黏度

圖片3.jpg

圖2. 流變測(cè)試:黏度(剪切速率:10s-1,37℃)



溫敏行為

圖片4.jpg

圖3. 流變測(cè)試:降/升溫相轉(zhuǎn)變溫度及5℃凍膠強(qiáng)度(振蕩溫度掃描:40℃→4℃→40℃,5℃/min,應(yīng)變1%,角速率5rad/s)



儲(chǔ)能模量

圖片5.jpg

圖4. 流變測(cè)試:光固化過(guò)程及最終凝膠儲(chǔ)能模量(振蕩時(shí)間掃描:應(yīng)變1%,角速率5rad/s;405nm光源,30mW/cm2,30s)



壓縮模量

圖片6.jpg

圖5.三種型號(hào)不同濃度的GelMA壓縮模量:EFL-LS-1601-405光源固化30s


SEM

圖片7.jpg

圖6.水凝膠凍干樣本電鏡示意圖。左:澆注水凝膠SEM;右:3D打印水凝膠支架SEM


生物相容性

GelMA已廣泛用于各類干細(xì)胞、癌細(xì)胞、內(nèi)皮細(xì)胞、神經(jīng)細(xì)胞、心肌細(xì)胞、肝細(xì)胞、軟骨細(xì)胞等細(xì)胞的2D/3D培養(yǎng),細(xì)胞存活率大于90%,細(xì)胞功能化良好。

圖片8.jpg

圖7.骨髓間充質(zhì)干細(xì)胞(BMSC)在GelMA表面及內(nèi)部培養(yǎng)效果


3D打印性能

EFL-GM系列水凝膠固化速度快且機(jī)械性能可調(diào),適用于擠出式生物3D打印與投影式光固化生物3D打印(DLP)。配合EFL團(tuán)隊(duì)自主研發(fā)的多功能擠出式生物3D打印機(jī)(EFL-BP-66系列)和投影式光固化生物3D打印機(jī)(EFL-BP-86系列),可輕松實(shí)現(xiàn)GelMA復(fù)雜結(jié)構(gòu)制造,載細(xì)胞打印存活率可達(dá)90%,細(xì)胞功能化良好。


圖片9.jpg

圖8.投影式光固化3D打印GelMA仿生微結(jié)構(gòu):神經(jīng)導(dǎo)管、脊髓結(jié)構(gòu)、血管結(jié)構(gòu)(上);擠出3D打印GelMA復(fù)雜水凝膠結(jié)構(gòu):網(wǎng)格支架、耳朵、鼻子(下)


圖片10.jpg

圖9.3D打印載細(xì)胞(BMSC)水凝膠支架



產(chǎn)品說(shuō)明書

  • 【產(chǎn)品說(shuō)明書】EFL-GM系列(5g包裝,不含引發(fā)劑)-甲基丙烯?;髂z

  • 【產(chǎn)品說(shuō)明書】EFL-GM系列(1g包裝,含引發(fā)劑)-甲基丙烯?;髂z

答疑


應(yīng)用案例

【牙周炎治療應(yīng)用】黑磷量子點(diǎn)修飾的 ADSCs 療法:破解牙周炎骨質(zhì)流失難題

【牙周炎治療應(yīng)用】《Bioactive Materials》:如何利用GelMA水凝膠貼片促進(jìn)牙周炎組織修復(fù)?

【牙周炎治療應(yīng)用】如何利用GelMA水凝膠負(fù)載外泌體治療牙周炎?

【牙髓再生應(yīng)用】Biomaterials:如何利用GelMA 微球?qū)崿F(xiàn)牙髓再生?

【牙髓再生應(yīng)用】如何利用GelMA水凝膠實(shí)現(xiàn)活體牙髓治療?

【牙本質(zhì)過(guò)敏癥治療應(yīng)用】中科院長(zhǎng)春應(yīng)化所《Adv. Sci.》:黑磷納米復(fù)合水凝膠+生物礦化協(xié)同治療牙本質(zhì)超敏反應(yīng)

【骨修復(fù)與再生應(yīng)用】雙相載細(xì)胞活性支架:生物3D打印技術(shù)革新骨-軟骨缺損修復(fù)與再生

【骨修復(fù)與再生應(yīng)用】《AHM》:給GelMA加點(diǎn)dECM,有望促進(jìn)骨軟骨修復(fù)

【骨修復(fù)與再生應(yīng)用】《AHM》:新型GelMA水凝膠!具有光固化、可注射和高度粘合性

【骨修復(fù)與再生應(yīng)用】如何利用Fe2O3/GelMA復(fù)合水凝膠實(shí)現(xiàn)受損軟骨組織的修復(fù)與再生?

【骨修復(fù)與再生應(yīng)用】基于GelMA的工程多孔微球和多細(xì)胞組裝的協(xié)同作用促進(jìn)成骨和血管生成

【骨修復(fù)與再生應(yīng)用】《AHM》:蟲草素+外泌體,GelMA水凝膠促進(jìn)老年骨修復(fù)

【骨修復(fù)與再生應(yīng)用】《AM》:如何利用抗體介導(dǎo)的靶向水凝膠微球減緩早期骨關(guān)節(jié)炎惡化?

【骨修復(fù)與再生應(yīng)用】GelMA水凝膠,再次登頂AM

【骨修復(fù)與再生應(yīng)用】用于3D生物打印的骨免疫調(diào)節(jié)生物墨水實(shí)現(xiàn)臨界尺寸骨缺損再生

【骨修復(fù)與再生應(yīng)用】《Materials Today Bio》:如何利用GelMA水凝膠微球促進(jìn)血管化骨再生

【骨修復(fù)與再生應(yīng)用】近期GelMA骨修復(fù)論文速覽,需要的進(jìn)來(lái)看看!

【骨修復(fù)與再生應(yīng)用】成骨最全表征《Adv. Sci.》:GelMA/Alg-MA搭配BP打造水凝膠光熱系統(tǒng)加速骨再生

【骨修復(fù)與再生應(yīng)用】《Materials Today Bio》:可注射載缺氧預(yù)處理的軟骨祖細(xì)胞的GelMA微球用于增強(qiáng)骨關(guān)節(jié)炎治療

【骨修復(fù)與再生應(yīng)用】基于GelMA的可注射光固化水凝膠用于軟骨組織再生

【椎間盤退變應(yīng)用】天津醫(yī)科大學(xué)《Chemical Engineering Journal》:髓核和纖維環(huán)組合的生物活性支架增強(qiáng)椎間盤缺損再生

【角膜修復(fù)應(yīng)用】GelMA水凝膠,Science子刊認(rèn)可的角膜修復(fù)革命!

【角膜修復(fù)應(yīng)用】應(yīng)用簡(jiǎn)介!可注射GelMA水凝膠用于重建角膜基質(zhì)

【3D腫瘤建模應(yīng)用】GelMA水凝膠:3D腫瘤建模的革命性技術(shù)

【鐵死亡療法應(yīng)用】突破性創(chuàng)新!GelMA水凝膠引領(lǐng)鐵死亡療法新時(shí)代!

【干燥綜合征治療應(yīng)用】GelMA水凝膠培養(yǎng)類器官實(shí)現(xiàn)唾液腺“再生”,發(fā)文《CEJ》

【消化道出血治療應(yīng)用】AM:藍(lán)光激活,秒級(jí)止血!GelMA與自組裝多肽打造消化道出血治療新利器

【基質(zhì)剛度研究應(yīng)用】AMI :如何利用基質(zhì)剛度調(diào)節(jié)淋巴內(nèi)皮細(xì)胞以促進(jìn)淋巴管生成

【基質(zhì)剛度研究應(yīng)用】Bioactive Materials:基質(zhì)剛度調(diào)節(jié)內(nèi)皮頂端細(xì)胞的形成

【基質(zhì)剛度研究應(yīng)用】《Bioactive Materials》:劉昌勝院士--水凝膠基質(zhì)強(qiáng)度精準(zhǔn)調(diào)控破骨細(xì)胞分化

【基質(zhì)剛度研究應(yīng)用】三維GelMA微孔陣列:探索剛度依賴性基質(zhì)細(xì)胞與腫瘤的相互作用

【生長(zhǎng)板損傷修復(fù)應(yīng)用】負(fù)載外泌體的可注射光交聯(lián)脫細(xì)胞軟骨基質(zhì)水凝膠促進(jìn)生長(zhǎng)板損傷修復(fù)

【傷口愈合應(yīng)用】基于雙負(fù)載脂質(zhì)體的多功能納米復(fù)合水凝膠輸送系統(tǒng)用于無(wú)疤痕傷口愈合

【傷口愈合應(yīng)用】GelMA水凝膠負(fù)載凋亡小體:糖尿病傷口愈合的新策略

【傷口愈合應(yīng)用】GelMA水凝膠負(fù)載miR-17-5p 工程化sEV:糖尿病傷口愈合的新策略

【傷口愈合應(yīng)用】《Bioactive Materials》:如何利用GelMA多功能復(fù)合水凝膠促進(jìn)血管生成和傷口愈合?

【傷口愈合應(yīng)用】《Advanced science 》如何利用GelMA水凝膠“微籠”促進(jìn)糖尿病傷口愈合

【傷口愈合應(yīng)用】《Biomaterials Research》:如何利用GelMA水凝膠實(shí)現(xiàn)皮膚傷口愈合和血管再生?

【傷口愈合應(yīng)用】《AHM》:如何利用GelMA微針促血管生成抑制炎癥治療皮膚傷口?

【傷口愈合應(yīng)用】負(fù)載Netrin-1的GelMA水凝膠加速糖尿病傷口原位愈合

【薄型子宮內(nèi)膜治療應(yīng)用】《Small》:GelMA水凝膠微球用于治療薄型子宮內(nèi)膜

【神經(jīng)修復(fù)與再生應(yīng)用】柴人杰等《Aggregate》:GelMA水凝膠導(dǎo)管促進(jìn)神經(jīng)再生

【肥厚性瘢痕治療應(yīng)用】國(guó)家杰青課題組《NC》:如何利用GelMA微針抑制增生性瘢痕?

【缺血再灌注損傷修復(fù)應(yīng)用】《Int. J. Biol. Macromol.》:GelMA微針實(shí)現(xiàn)缺血再灌注損傷的保護(hù)

【脊髓損傷修復(fù)應(yīng)用】GelMA水凝膠應(yīng)用-脊髓損傷修復(fù)

【脊髓損傷修復(fù)應(yīng)用】《AHM》:未來(lái)可期:GelMA水凝膠--治療脊髓損傷的潛在臨床前平臺(tái)

【脊髓炎治療應(yīng)用】《Biofabrication》:GelMA/海藻酸鹽水凝膠微球治療骨髓炎

【創(chuàng)傷性腦損傷修復(fù)應(yīng)用】用于快速止血和組織再生的GelMA水凝膠,《AHM》+1

【外泌體控釋應(yīng)用】《ACS Nano》:有關(guān)GelMA水凝膠!構(gòu)建生物素--親和素系統(tǒng)耦合緩控釋外泌體的普適性策略

【構(gòu)建血管化肝組織應(yīng)用】3D擠出打印負(fù)載GFP-HepG2球體的GelMA水凝膠墨水用于構(gòu)建血管化肝組織

GelMA應(yīng)用:強(qiáng)韌性水凝膠

GelMA應(yīng)用:外泌體負(fù)載與控釋

GelMA應(yīng)用:生長(zhǎng)因子負(fù)載與控釋

GelMA應(yīng)用:軟骨修復(fù)與再生

GelMA應(yīng)用:骨修復(fù)與再生

GelMA應(yīng)用:微球

GelMA應(yīng)用:腫瘤模型

GelMA應(yīng)用:微流控

GelMA應(yīng)用:粘附型水凝膠

GelMA應(yīng)用:可注射水凝膠

GelMA應(yīng)用:藥物負(fù)載與控釋

GelMA應(yīng)用:導(dǎo)電型水凝膠

GelMA應(yīng)用:微針

GelMA應(yīng)用:神經(jīng)修復(fù)與再生

【產(chǎn)品應(yīng)用】GelMA水凝膠應(yīng)用集錦

用戶論文

A biomimetic skin microtissue biosensor for the detection of fish parvalbumin.Bioelectrochemistry.2024

Biomimetic gastric microtissue electrochemical biosensors for ovalbumin detection.Biosensors and Bioelectronics.2025

3D bio-printing-based vascular-microtissue electrochemical biosensor for fish parvalbumin detection.Food Chemistry.2024

Biofabrication of Tissue-Engineered Cartilage Constructs Through Faraday Wave Bioassembly of Cell-Laden Gelatin Microcarriers.Advanced Healthcare Materials.2024

3D mesenchymal stem cell exosome-functionalized hydrogels for corneal wound healing.Journal of Controlled Release.2025

Cerium Oxide Nanoparticles-Reinforced GelMA Hydrogel Loading Bone Marrow Stem Cells with Osteogenic and Inflammatory Regulatory Capacity for Bone Defect Repair.ACS Applied Materials & Interfaces.2024

Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair.Materials Today Bio.2025

Biomineralized Nanocomposite-Integrated Microneedle Patch for Combined Brachytherapy and Photothermal Therapy in Postoperative Melanoma Recurrence and Infectious Wound Healing.Advanced Science.2025

3D pancreatic ductal adenocarcinoma desmoplastic model: Glycolysis facilitating stemness via ITGAV-PI3K-AKT-YAP1.Biomaterials Advances.2025

Hybrid hydrogel loaded with natural plant extract accelerates diabetic wound healing via ROS scavenging and immunoregulation.Chemical Engineering Journal.2024

Establishment of human minor salivary gland organoids in laminin-GelMA hydrogel from healthy individuals and Sj?gren’s disease patients.Chemical Engineering Journal.2024

Hierarchically Porous Microgels with Interior Spiral Canals for High-Efficiency Delivery of Stem Cells in Wound Healing.Small.2024

Combined nucleus pulposus and annulus fibrosus bioactive scaffolds enhance intervertebral disc defect regeneration.Chemical Engineering Journal.2024

Functionalized Nanozyme Microcapsules Targeting Deafness Prevention via Mitochondrial Homeostasis Remodeling.Advanced Materials.2024

Piezo1 Mediates Glycolysis-Boosted Pancreatic Ductal Adenocarcinoma Chemoresistance within a Biomimetic Three-Dimensional Matrix Stiffness.ACS Biomaterials Science & Engineering.2024

The M2 Macrophages Derived Migrasomes From the Surface of Titania Nanotubes Array as a New Concept for Enhancing Osteogenesis.Advanced Healthcare Materials.2024

Matrix Stiffness of GelMA Hydrogels Regulates Lymphatic Endothelial Cells toward Enhanced Lymphangiogenesis.ACS Applied Materials & Interfaces.2024

Soft-lithographically defined template for arbitrarily patterned acoustic bioassembly.Biofabrication.2024

3D printing of stiff, tough, and ROS-scavenging nanocomposite hydrogel scaffold for in situ corneal repair.Acta Biomaterialia.2025

Black phosphorus quantum dot-modified ADSCs as a novel therapeutic for periodontitis bone loss coupling of osteogenesis and osteoimmunomodulation.Materials Today Bio.2024

Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair.Materials Today Bio.2024

Implantation of hydrogel-liposome nanoplatform inhibits glioblastoma relapse by inducing ferroptosis.Asian Journal of Pharmaceutical Sciences.2023

Epithelial differentiation of gingival mesenchymal stem cells enhances re-epithelialization for full-thickness cutaneous wound healing.Stem Cell Research & Therapy.2024

A bilayer hydrogel mimicking the periosteum-bone structure for innervated bone regeneration.Journal of Materials Chemistry B.2024

Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage.iScience.2024

Cell-free fat extract-loaded microneedles attenuate inflammation-induced apoptosis and mitochondrial damage in tendinopathy.Materials Today Bio.2023

A 3D-printed microdevice encapsulates vascularized islets composed of iPSC-derived β-like cells and microvascular fragments for type 1 diabetes treatment.Biomaterials.2025

A Programmable Oral Nanomotor Microcapsule for the Treatment of Inflammatory Bowel Disease.Advanced Functional Materials.2024

Selenomethionine in gelatin methacryloyl hydrogels: Modulating ferroptosis to attenuate skin aging.Bioactive Materials.2024

T. gondii excretory proteins promote the osteogenic differentiation of human bone mesenchymal stem cells via the BMP/Smad signaling pathway.Journal of Orthopaedic Surgery and Research.2024

Acoustic Cell Patterning for Structured Cell-Laden Hydrogel Fibers/Tubules.Advanced Science.2024

Graphene Oxide Quantum Dots-Preactivated Dental Pulp Stem Cells/GelMA Facilitates Mitophagy-Regulated Bone Regeneration.International Journal of Nanomedicine.2024

Removal‐Free and Multicellular Suspension Bath‐Based 3D Bioprinting.Advanced Materials.2024

A Micromanipulation-Actuated Large-Scale Screening to Identify Optimized Microphysiological Model Parameters in Skeletal Muscle Regeneration.Advanced Science.2024

Injectable photocrosslinkable acellular cartilage matrix hydrogel loaded with exosomes for promoting growth plate injury repair.Chemical Engineering Journal.2024

Preparation of photo-crosslinked microalgae-carboxymethyl chitosan composite hydrogels for enhanced wound healing.Carbohydrate Polymers.2025

Bio-functional immunomodulatory europium-doped hydroxyapatite nanorods for osteochondral repair via CDH5-RAS-RAF-MEK-ERK-CSF1 axis.Chemical Engineering Journal.2024

Functionalized 3D-printed GelMA/Laponite hydrogel scaffold promotes BMSCs recruitment through osteoimmunomodulatory enhance osteogenic via AMPK/mTOR signaling pathway.Materials Today Bio.2024

Conductive GelMA/PEDOT: PSS Hybrid Hydrogel as a Neural Stem Cell Niche for Treating Cerebral Ischemia-Reperfusion Injury.Frontiers in Materials.2022

Composition Tuning of Semi-Open Cell Carriers via Phase Freeze-Shrink Self-Molding.ACS Nano.2024

The preventive effect of photocrosslinked Hep/GelMA hydrogel loaded with PRF on MRONJ.BMC Oral Health.2024

A carbon dot nanozyme hydrogel enhances pulp regeneration activity by regulating oxidative stress in dental pulpitis.Journal of Nanobiotechnology.2024

A wireless, battery-free microneedle patch with light-cured swellable hydrogel for minimally-invasive glucose detection.Nano Energy.2024

Fabrication of a 3D bioprinting model for posterior capsule opacification using GelMA and PLMA hydrogel-coated resin.Regenerative Biomaterials.2024

IL-1ra loaded chondroitin sulfate-functionalized microspheres for minimally invasive treatment of intervertebral disc degeneration.Acta Biomaterialia.2024

Implantable Microneedle-Mediated Eradication of Postoperative Tumor Foci Mitigates Glioblastoma Relapse.Advanced Materials.2024

Stem cell recruitment polypeptide hydrogel microcarriers with exosome delivery for osteoarthritis treatment.Journal of Nanobiotechnology.2024

Balancing macrophage polarization via stem cell-derived apoptotic bodies for diabetic wound healing.Med.2024

Bone tissue engineering based on sustained release of MiR29c-modified framework nucleic acids from an injectable hydrogel.Chemical Engineering Journal.2024

Biomimetic Tertiary Lymphoid Structures with Microporous Annealed Particle Scaffolds for Cancer Postoperative Therapy.ACS Nano.2024

ZIF-8-Modified Black Phosphorus Nanosheets Incorporated into Injectable Dual-Component Hydrogels for Enhanced Photothermal Antibacterial and Osteogenic Activities.ACS Applied Materials & Interfaces.2024

VDAC1-enriched apoptotic extracellular vesicles emerge as an autophagy activator orchestrating PDLSC-based bone regeneration.Chemical Engineering Journal.2024

Efficient Light-Based Bioprinting via Rutin Nanoparticle Photoinhibitor for Advanced Biomedical Applications.ACS Nano.2024

Functional extracellular vesicles from SHEDs combined with gelatin methacryloyl promote the odontogenic differentiation of DPSCs for pulp regeneration.Journal of Nanobiotechnology.2024

Application of photocrosslinked gelatin, alginate and dextran hydrogels in the in vitro culture of testicular tissue.International Journal of Biological Macromolecules.2024

Biomimetic Hydrogels Promote Pseudoislet Formation to Improve Glycemic Control in Diabetic Mice.ACS Biomaterials Science & Engineering.2024

A differential-targeting core–shell microneedle patch with coordinated and prolonged release of mangiferin and MSC-derived exosomes for scarless skin regeneration.Materials Horizons.2024

Gelatin methacryloyl microneedle loaded with 3D-MSC-Exosomes for the protection of ischemia-reperfusion.International Journal of Biological Macromolecules.2024

A Multifunctional Nanocomposite Hydrogel Delivery System Based on Dual‐Loaded Liposomes for Scarless Wound Healing.Advanced Healthcare Materials.2024

A Janus Microsphere Delivery System Orchestrates Immunomodulation and Osteoinduction by Fine-tuning Release Profiles.Small.2024

Tracing Immunological Interaction in Trimethylamine N-Oxide Hydrogel-Derived Zwitterionic Microenvironment During Promoted Diabetic Wound Regeneration.Advanced Materials.2024

Gastric Cancer Assembloids Derived from Patient-Derived Xenografts: A Preclinical Model for Therapeutic Drug Screening.Small Methods.2024

Three-dimensional bioprinting biphasic multicellular living scaffold facilitates osteochondral defect regeneration.Interdisciplinary Materials.2024

Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction.ACS Biomaterials Science & Engineering.2024

Engineered hsa-miR-455-3p-Abundant Extracellular Vesicles Derived from 3D-Cultured Adipose Mesenchymal Stem Cells for Tissue-Engineering Hyaline Cartilage Regeneration.Advanced healthcare materials.2024

Providing biomimetic microenvironment for pulp regeneration via hydrogel-mediated sustained delivery of tissue-specific developmental signals.Materials Today Bio.2024

Netrin-1 co-cross-linked hydrogel accelerates diabetic wound healing in situ by modulating macrophage heterogeneity and promoting angiogenesis.Bioactive Materials.2024

Osteoimmunomodulatory bioinks for 3D bioprinting achieve complete regeneration of critical-sized bone defects.Composites Part B: Engineering.2024

A facile and smart strategy to enhance bone regeneration with efficient vitamin D3 delivery through sterosome technology.Journal of controlled release.2024

3D printing of MXene composite hydrogel scaffolds for photothermal antibacterial activity and bone regeneration in infected bone defect models.Nanoscale.2022

An Injectable Integration ofAutologous Bioactive Concentrated Growth Factor and Gelatin Methacrylate Hydrogel with Efficient Growth Factor Release and 3D Spatial Structure for Accelerated Wound Healing.Macromolecule Bioscience.2023

Methacrylated gelatin and platelet-rich plasma based hydrogels promote regeneration of critical-sized bone defects.Regenerative Biomaterials.2024

Biotin-Avidin System-Based Delivery Enhances the Therapeutic Performance of MSC-Derived Exosomes.ACS Nano.2023

Enhanced bone regeneration with bioprinted GelMA/Bentonite scaffoldsinspired by bone matrix.Virtual and Physical Prototyping.2024

Bioceramic modular tissue-engineered bone with rapid vascularization for large bone defects.Ceramics International.2024

A Spatiotemporal Controllable Biomimetic Skin for Accelerating Wound Repair.Small.2024

Double-Network Hydrogel with Strengthened Mechanical Property for Controllable Release of Antibacterial Peptide.Biomacromolecules.2024

Ultrasoft bioadhesive hydrogel as a versatile platform for the delivery of basic fibroblast growth factor to repair traumatic brain injury.Chemical Engineering Journal.2024

Targeting Grancalcin Accelerates Wound Healing by Improving Angiogenesis in Diabetes.Advanced Science.2024

MiR-17-5p-engineered sEVs Encapsulated in GelMA Hydrogel Facilitated Diabetic Wound Healing by Targeting PTEN and p21.Advanced Science.2024

Individualized bio-scaffold encapsulating siPTEN-loaded exosomes for promoting neuronal regeneration in spinal cord injury.Composites Part B: Engineering.2024

ZIF-8 modified multifunctional injectable photopolymerizable GelMA hydrogel for the treatment of periodontitis.Acta Biomaterialia.2022

Metabolic Response Modulations by Zwitterionic Hydrogels for Achieving Promoted Bone Regeneration.Advanced Functional Materials.2023

Transplantation of active nucleus pulposus cells with a keep-charging hydrogel microsphere system to rescue intervertebral disc degeneration.Journal of Nanobiotechnology.2023

Injectable Living Probiotic Dressing Built by Droplet-Based Microfluidics and Photo-Cross-Linking to Prevent Pathogenic Infection and Promote Wound Repair.Advanced Healthcare Materials.2023

Antifungal bio-coating of endotracheal tube built by overexpressing the MCP1 gene of Saccharomyces boulardii and employing hydrogel as a "house" to antagonize Candida albicans.Biomaterials Research.2023

Matrix stiffness triggers chemoresistance through elevated autophagy in pancreatic ductal adenocarcinoma.Biomaterials Science.2023

Bioinspired nanovesicles released from injectable hydrogels facilitate diabetic wound healing by regulating macrophage polarization and endothelial cell dysfunction.Journal of Nanobiotechnology.2023

All-in-one smart dressing for simultaneous angiogenesis and neural regeneration.Journal of Nanobiotechnology.2023

Varying Mechanical Forces Drive Sensory Epithelium Formation.Science Advances.2023

Oriented artificial niche provides physical-biochemical stimulations for rapid nerve regeneration.Materials Today Bio.2023

Engineering Highly Vascularized Bone Tissues by 3D Bioprinting of Granular Prevascularized Spheroids.ACS Applied Materials & Interfaces.2023

Expanding Embedded 3D Bioprinting Capability for Engineering Complex Organs with Freeform Vascular Networks.Advanced Materials.2023

Core-Shell Droplet-Based Microfluidic Screening System for Filamentous Fungi.ACS Sensors.2023

Corneal stromal filler injection of gelatin-based photocurable hydrogels for maintaining the corneal thickness and reconstruction of corneal stroma.Composites Part B: Engineering.2023

Biomimetic Microenvironmental Stiffness Boosts Stemness of Pancreatic Ductal Adenocarcinoma via Augmented Autophagy.ACS Biomaterials Science & Engineering.2023

Three-in-one customized bioink for islet organoid: GelMA/ECM/PRP orchestrate pro-angiogenic and immunoregulatory function.Colloids and Surfaces B: Biointerfaces.2023

3D printing of vascularized hepatic tissues with a high cell density and heterogeneous microenvironment.Biofabrication.2023

Application of Bone Marrow-Derived Macrophages Combined with Bone Mesenchymal Stem Cells in Dual-Channel Three-Dimensional Bioprinting Scaffolds for Early Immune Regulation and Osteogenic Induction in Rat Calvarial Defects.ACS Applied Materials & Interfaces.2022

A Hierarchical 3D Graft Printed with Nanoink for Functional Craniofacial Bone Restoration.Advanced Functional Materials.2023

Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury.Nature Communications.2023

Bioprinted Scaffold Remodels the Neuromodulatory Microenvironment for Enhancing Bone Regeneration.Advanced Functional Materials.2023

“Slow walk” mimetic tensile loading maintains human meniscus tissue resident progenitor cells homeostasis in photocrosslinked gelatin hydrogel.Bioactive Materials.2023

An Injectable Integration ofAutologous Bioactive Concentrated Growth Factor and Gelatin Methacrylate Hydrogel with Efficient Growth Factor Release and 3D Spatial Structure for Accelerated Wound Healing.Macromolecular Bioscience.2023

Integrative Analysis Reveals the Diverse Effects of 3D Stiffness upon Stem Cell Fate.International Journal of Molecular Science.2023

4D Printing of Personalized-Tunable Biomimetic Periosteum with Anisotropic Microstructure for Accelerated Vascularization and Bone Healing.Advanced Healthcare Materials.2023

Gelatin methacryloyl hydrogel, from standardization, performance, to biomedical application.Advanced Healthcare Materials.2023

Formation theory and printability of photocurable hydrogel for 3D bioprinting.Advanced Functional Materials.2023

Targeting Endogenous Reactive Oxygen Species Removal and Regulating Regenerative Microenvironment at Annulus Fibrosus Defects Promote Tissue Repair.ACS nano.2023

Adjustable extracellular matrix rigidity tumor model forstudying stiffness dependent pancreatic ductal adenocarcinomas progression and tumor immunosuppression.Bioengineering & Translational Medicine.2023

Repairing Avascular Meniscal Lesions by Recruiting Endogenous Targeted Cells Through Bispecific Synovial-Meniscal Aptamers.The American Journal of Sports Medicine.2023

Creating a semi-opened micro-cavity ovary through sacrificial microspheres as an in vitro model for discovering the potential effect of ovarian toxic agents.Bioactive Materials.2023

Loading neural stem cells on hydrogel scaffold improves cell retention rate and promotes functional recovery in traumatic brain injury.Materials Today Bio.2023

3D Bioprinted GelMA-Nanoclay Hydrogels Induce Colorectal Cancer Stem Cells Through Activating Wnt/β-Catenin Signaling.Small.2022

Nanotherapy for bone repair: milk-derived small extracellular vesicles delivery of icariin.Drug Delivery.2023

3D “honeycomb” cell/carbon nanofiber/gelatin methacryloyl (GelMA) modified screen-printed electrode for electrochemical assessment of the combined toxicity of deoxynivalenol family mycotoxins.Bioelectrochemistry.2021

Gelatin methacryloyl (GelMA) loaded Gelatin methacryloyl (GelMA) loaded with concentrated hypoxic pretreated adipose-derived mesenchymal stem cells(ADSCs) conditioned medium promotes wound healing and vascular regeneration in aged skin.Biomaterials Research.2023

Experimental study on repair of cartilage defects in the rabbits with GelMA-MSCs scaffold prepared by three-dimensional bioprinting.International Journal of Bioprinting.2023

3D bioprinting of in situ vascularized tissue engineered bone for repairing large segmental bone defects.Materials Today Bio.2022

Bioprinting EphrinB2-modified DPSCs with enhanced osteogenic capacity for alveolar bone engineering.Tissue Engineering Part A.2023

Equivalent Circuit Models for Magnetoelastic Resonance Sensors with Various Surface Loadings.IEEE Sensors Journal.2023

3D printed mesoporous bioactive glass/GelMA biomimetic scaffolds for osteogenic/cementogenic differentiation of periodontal ligament cells.Frontiers in Bioengineering and Biotechnology.2022

3D Printing Mini-Capsule Device for Islet Delivery to Treat Type 1 Diabetes.ACS Applied Materials & Interfaces.2022

3D printing of reduced glutathione grafted gelatine methacrylate hydrogel scaffold promotes diabetic bone regeneration by activating PI3K/Akt signaling pathway.International Journal of Biological Macromolecules.2022

3D-bioprinted Recombination Structure of Hertwig’s Epithelial Root Sheath Cells and Dental Papilla Cells for Alveolar Bone Regeneration.International Journal of Bioprinting.2022

A 3D-bioprinted functional module based on decellularized extracellular matrix bioink for periodontal regeneration.Advanced science.2022

3D bioprinting of proangiogenic constructs with induced immunomodulatory microenvironments through a dual cross-linking procedure using laponite incorporated bioink.Composites Part B: Engineering.2022

3D Printing of Cell-Laden Microgel-Based Biphasic Bioink with Heterogeneous Microenvironment for Biomedical Applications.Advanced Functional Materials.2021

A decellularized spinal cord extracellular matrix-gel/GelMA hydrogel three-dimensional composite scaffold promotes recovery from spinal cord injury via synergism with human menstrual blood-derived stem cells.Journal of Materials Chemistry B.2022

A versatile embedding medium for freeform bioprinting with multi-crosslinking methods.Biofabrication.2022

An artificial LAMA2-GelMA hydrogel microenvironment for the development of pancreatic endocrine progenitors.Biomaterials.2022

An injectable curcumin-releasing organohydrogel with non-drying property and high mechanical stability at low-temperature for expedited skin wound care.Journal of Materials Science & Technology.2023

Analysis of the potential role of photocurable hydrogel in patient-derived glioblastoma organoid culture through RNA sequencing.Biomaterials Science.2022

3D printing of gelatin methacrylate-based nerve guidance conduits with multiple channels.Materials & Design.2020

3D-bioprinted peptide coupling patches for wound healing.Materials Today Bio.2022

A biomimetic “intestinal microvillus” cell sensor based on 3D bioprinting for the detection of wheat allergen gliadin.Bioelectrochemistry.2021

Adipose-derived mesenchymal stromal cell-derived exosomes promote tendon healing by activating both SMAD1/5/9 and SMAD2/3.Stem Cell Research & Therapy.2021

Biodegradable Dual-crosslinked Adhesive Glue for Fixation and Promotion of Osteogenesis.Chemical Engineering Journal.2022

Biomimetic peridontium patches for functional periodontal regeneration.Advanced Healthcare Materials.2022

Cell Infiltrative Inner Connected Porous Hydrogel Improves Stem Cell Migration and Differentiation for Functional Repair of Spinal Cord Injury.ACS Biomaterials Science & Engineering.2022

circ_0003204 regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p/HDAC4 axis.International Journal of Oral Science.2022

Congenital microtia patients: the genetically engineered exosomes released from porous gelatin methacryloyl hydrogel for downstream small RNA profiling, functional modulation of microtia chondrocytes and tissue-engineered ear cartilage regeneration.Journal of Nanobiotechnology.2022

Construction of a decellularized spinal cord matrix/GelMA composite scaffold and its effects on neuronal differentiation of neural stem cells.Journal of Biomaterials Science Polymer Edition.2022

Engineering the viscoelasticity of gelatin methacryloyl (GelMA) hydrogels via small “dynamic bridges” to regulate BMSC behaviors for osteochondral regeneration.Bioactive Materials.2023

Epidermal growth factor-loaded microspheres/hydrogel composite for instant hemostasis and liver regeneration.Smart Materials in Medicine.2023

Fabrication of hydrogels with adjustable mechanical properties through 3D cell-laden printing technology.Colloids and Surfaces A: Physicochemical and Engineering Aspects.2022

Gelatin methacryloyl-alginate core-shell microcapsules as efficient delivery platforms for prevascularized microtissues in endodontic regeneration.Acta Biomaterialia.2022

Biodegradable hydrogel with thermo-response and hemostatic effect for photothermal enhanced anti-infective therapy.Nano Today.2021

Graded-Three-Dimensional Cell-Encapsulating Hydrogelas a Potential Biologic Scaffold for Disc Tissue Engineering.Tissue Engineering and Regenerative Medicine.2022

Heterogeneous spheroids with tunable interior morphologies by droplet-based microfluidics.Biofabrication.2022

High-resolution 3D printing of angle-ply annulus fibrosus scaffolds for intervertebral disc regeneration.Biofabrication.2022

Low-intensity pulsed ultrasound promotes cell viability and inhibits apoptosis of H9C2 cardiomyocytes in 3D bioprinting scaffolds via PI3K-Akt and ERK1/2 pathways.Journal of Biomaterials Applications.2022

Low-Swelling Adhesive Hydrogel with Rapid Hemostasis and Potent Anti-Inflammatory Capability for Full-Thickness Oral Mucosal Defect Repair.ACS Applied Materials & Interfaces.2022

Microtissue-Based Bioink as a Chondrocyte Microshelter for DLP Bioprinting.Advanced Healthcare Materials.2022

Bioprinted Constructs that Mimic the Ossification Center Microenvironment for Targeted Innervation in Bone Regeneration.Advanced Functional Materials.2021

Mineralized Enzyme-Based Biomaterials with Superior Bioactivities for Bone Regeneration.ACS Applied Materials & Interfaces.2022

Orchestration of energy metabolism and osteogenesis by Mg2+ facilitates low-dose BMP-2-driven regeneration.Bioactive Materials.2022

Donut-like MOFs of copper/nicotinic acid and composite hydrogels with superior bioactivity for rh-bFGF delivering and skin wound healing.Journal of Nanobiotechnology.2021

Electrical stimulation of neonatal rat cardiomyocytes using conductive polydopamine-reduced graphene oxide-hybrid hydrogels for constructing cardiac microtissues.Colloids and Surfaces B Biointerfaces.2021

Photocurable Hydrogel Substrate—Better Potential Substitute on Bone-Marrow-Derived Dendritic Cells Culturing.Materials.2022

Regulable Supporting Baths for Embedded Printing of Soft Biomaterials with Variable Stiffness.ACS Applied Materials & Interfaces.2022

A bioartificial liver support system integrated with a DLM/GelMA-based bioengineered whole liver for prevention of hepatic encephalopathy via enhanced ammonia reduction.Biomaterials Science.2020

A smart hydrogel system for visual detection of glucose.Biosensors and Bioelectronics.2019

Enzyme- and UV-Mediated Double-Network Hybrid Hydrogels for 3D Cell Culture application.Macromolecular Bioscience.2021

Fabrication of Thermoresponsive Hydrogel Scaffolds with Engineered Microscale Vasculatures.Advanced Functional Materials.2021

Gelatin methacrylate hydrogel scaffold carrying resveratrol-loaded solid lipid nanoparticles for enhancement of osteogenic differentiation of BMSCs and effective bone regeneration.Regenerative Biomaterials.2021

HtrA3-Mediated Endothelial Cell–Extracellular Matrix Crosstalk Regulates Tip Cell Specification.Advanced Functional Materials.2021

Hydrogel composite scaffolds with an attenuated immunogenicity component for bone tissue engineering applications.Journal of Materials Chemistry B.2021

Magnesium Ammonium Phosphate Composite Cell-Laden Hydrogel Promotes Osteogenesis and Angiogenesis In Vitro.ACS Omega.2021

Smart acoustic 3D cell construct assembly with high-resolution.Biofabrication.2022

Study on properties of 3D-printed GelMA hydrogel scaffolds with different nHA contents.Journal of Bioactive and Compatible Polymers.2022

Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis.Bioactive Materials.2022

Mechanically reinforced injectable bioactive nanocomposite hydrogels for in-situ bone regeneration.Chemical Engineering Journal.2022

Coaxial Extrusion of Tubular Tissue Constructs Using a Gelatin/GelMA Blend Bioink.ACS Biomaterials Science and Engineering.2019

Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty.Bioactive Materials.2022

Fabrication of vascular smooth muscle-like tissues based on self-organization of circumferentially aligned cells in microengineered hydrogels.Lab on a Chip.2020

Negative pressure wound therapy improves bone regeneration by promoting osteogenic differentiation via the AMPK-ULK1-autophagy axis.Autophagy.2021

Nitric Oxide Nanomotor Driving Exosomes_x005f_x005f_x005f_x005f_x005f_x0002_Loaded Microneedles for Achilles Tendinopathy Healing.ACS Nano.2021

Platelet lysate functionalized gelatin methacrylate microspheres for improving angiogenesis in endodontic regeneration.Acta Biomaterialia.2021

Potential Mechanisms of the Impact of Hepatocyte Growth Factor Gene-Modified Tendon Stem Cells on Tendon Healing.Frontiers in Cell and Developmental Biology.2021

Super-aligned carbon nanotubes and GelMA hydrogel composite scaffolds promote spiral ganglion neuron growth and orientation.Materials Today Nano.2022

hDPSC-laden GelMA microspheres fabricated using electrostatic microdroplet method for endodontic regeneration.Materials Science and Engineering: C.2021

Strontium ranelate promotes chondrogenesis through inhibition of the Wnt/β-catenin pathway.Stem Cell Research & Therapy.2021

The PCK2-glycolysis axis assists three-dimensional-stiffness maintaining stem cell osteogenesis.Bioactive Materials.2022

Targeting Endogenous Hydrogen Peroxide at Bone Defects Promotes Bone Repair.Advanced Functional Materials.2021

Three-Dimensional Printing Self-Healing Dynamic/Photocrosslinking Gelatin-Hyaluronic Acid Double-Network Hydrogel for Tissue Engineering.ACS Omega.2022

Three-Dimensional-Cultured MSC-Derived Exosome-Hydrogel Hybrid Microneedle Array Patch for Spinal Cord Repair.Nano Letters.2022

On-chip hydrogel arrays individually encapsulating acoustic formed multicellular aggregates for high throughput drug testing.Lab on a Chip.2020

Promoting 3D neuronal differentiation in hydrogel for spinal cord regeneration.Colloids and Surfaces B: Biointerfaces.2020

Stiffness of photocrosslinkable gelatin hydrogel influences nucleus pulposus cell propertiesin vitro.Journal of Cellular and Molecular Medicine.2020

Template-based fabrication of spatially organized 3D bioactive constructs using magnetic low-concentration gelation methacrylate (GelMA) microfibers.Soft Matter.2020

Tendon stem cell-derived exosomes regulate inflammation and promote the high-quality healing of injured tendon.Stem Cell Research & Therapy.2020

The acoustic droplet printing of functional tumor microenvironments.Lab on a Chip.2021

Three-dimensional bioprinting of multicell-laden scaffolds containing bone morphogenic protein-4 for promoting M2 macrophage polarization and accelerating bone defect repair in diabetes mellitus.Bioactive Materials.2021

Three-dimensional printed multiphasic scaffolds with stratified cell-laden gelatin methacrylate hydrogels for biomimetic tendon-to-bone interface engineering.Journal of Orthopaedic Translation.2020

Vascularized dental pulp regeneration using cell-laden microfiber aggregates.Journal of Materials Chemistry B.2022

VH298-loaded extracellular vesicles released from gelatin methacryloyl hydrogel facilitate diabetic wound healing by HIF-1α-mediated enhancement of angiogenesis.Acta Biomaterialia.2022

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